Microsatellite Instability by PCR – Test Update

This will take effect September 2, 2014

Overview and Clinical Utility:

PathGroup is pleased to announce the availability of Microsatellite Instability (MSI) analysis by PCR (MSI). Microsatellite instability is a result of a deficiency in a specific type of DNA repair capability called Mismatch Repair (MMR). Cells deficient in MMR have a reduced capability of repairing certain types of damage that naturally occur in their DNA, specifically mismatched bases. This deficiency is apparent in the replication of microsatellite sequences. Such microsatellite sequences are typically replicated and maintain a constant number of repeats. In MMR-deficient cells, the number of repeats can increase or decrease. Tumors that display MMR show a change in the size of microsatellite sequences from those seen in non-neoplastic tissue and are said to display MSI.

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